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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
27.58
Human Site:
T106
Identified Species:
40.44
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
T106
D
E
D
V
E
E
L
T
A
S
Q
R
E
A
A
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
R109
E
A
A
E
R
A
M
R
Q
R
D
R
E
A
G
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
T106
D
E
D
V
E
E
L
T
A
S
Q
R
E
A
A
Dog
Lupus familis
XP_541736
1001
113024
T204
D
E
D
V
E
E
L
T
A
S
Q
R
E
A
A
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
T106
D
E
D
V
E
E
L
T
A
S
Q
R
E
A
A
Rat
Rattus norvegicus
NP_001101343
905
102125
T107
D
E
D
V
E
E
L
T
A
S
Q
R
E
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
T114
D
E
D
V
E
E
L
T
A
S
Q
R
E
A
A
Chicken
Gallus gallus
NP_001006139
888
100332
R104
E
A
A
E
R
V
M
R
Q
R
D
R
E
L
E
Frog
Xenopus laevis
P55861
886
100243
S100
Q
R
E
A
A
E
Q
S
M
R
M
R
D
R
E
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
A100
A
R
A
E
A
E
A
A
M
R
R
R
D
R
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
E102
D
R
F
A
A
E
S
E
M
R
R
R
D
R
A
Honey Bee
Apis mellifera
XP_395109
1005
114136
E216
Y
S
E
M
S
Q
G
E
R
A
A
A
E
A
A
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
Y63
R
D
Q
L
K
R
N
Y
F
S
H
E
Y
R
L
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
A101
E
R
A
A
A
E
R
A
M
R
K
R
D
R
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
A72
P
G
E
Y
M
Q
P
A
S
D
A
V
S
E
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
S107
E
Q
Q
E
L
S
L
S
E
R
R
R
I
D
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
20
100
100
N.A.
100
100
N.A.
100
13.3
13.3
13.3
N.A.
26.6
20
6.6
13.3
P-Site Similarity:
100
33.3
100
100
N.A.
100
100
N.A.
100
26.6
33.3
26.6
N.A.
40
46.6
26.6
33.3
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
20
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
13
25
19
25
7
7
19
38
7
13
7
0
50
57
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
44
7
38
0
0
0
0
0
0
7
13
0
25
7
7
% D
% Glu:
25
38
19
25
38
63
0
13
7
0
0
7
57
7
19
% E
% Phe:
0
0
7
0
0
0
0
0
7
0
0
0
0
0
0
% F
% Gly:
0
7
0
0
0
0
7
0
0
0
0
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% I
% Lys:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% K
% Leu:
0
0
0
7
7
0
44
0
0
0
0
0
0
7
7
% L
% Met:
0
0
0
7
7
0
13
0
25
0
7
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% P
% Gln:
7
7
13
0
0
13
7
0
13
0
38
0
0
0
0
% Q
% Arg:
7
25
0
0
13
7
7
13
7
44
19
82
0
32
0
% R
% Ser:
0
7
0
0
7
7
7
13
7
44
0
0
7
0
0
% S
% Thr:
0
0
0
0
0
0
0
38
0
0
0
0
0
0
0
% T
% Val:
0
0
0
38
0
7
0
0
0
0
0
7
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
7
0
0
0
7
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _